Toxicological investigation of drugs in dentin can help in reconstructive identification of
corpses with extensive soft tissues destruction. In this work the analysis of benzodiazepines
in dental tissues was performed by LC/MS /MS . The method allows the identification
and quantitation of 16 benzodiazepines, after a solid phase extraction procedure. The
method was applied to 16 teeth real cases from patients under chronic treatment with
these drugs. Twelve out of these cases tested positive to any benzodiazepine, while 4
were negative. This means that a positive result confirms the use of the drug, but a
negative one does not exclude it