Y-chromosome infertility is usually caused by deletions of genetic material in
Azoospermia Factor (AZF) regions, localized in three nonoverlapping Yq regions – AZFa,
AZFb and AZFc. However, some of the Y-ST Rs routinely studied in Forensic Genetics with
multiplex kits are localized in these three regions giving rise to microdeletions observed
in some loci. Rare alleles were also encountered in these samples with Y-chromosome
structural changes. A complete Y-ST R profile in a sample from a female individual was
detected which may raise ethical implications. The aim of this work is to assess the
validity in the use of Y-ST R multiplex systems in structurally abnormal Y-chromosomes,
which may occur in forensic casework analysis